Cross-linked polymers of polycarboxylic acid USP/NF/ polacrilin potassium USP/NF
Polacrilin Potassium:
DESCRIPTION:
Polacrilin Potassium is a high purity pharmaceutical grade
weak acid cation exchange resin, potassium form as a free flowing powder. It is suitable
for use in the pharmaceutical applications such as taste
masking and tablet disintegration. Polacrilin Potassium is
derived from crosslinked polymethacrylic acid. Polacrilin Potassium conforms to the specification of
monograph for polacrilin potassium in USP/NF.
APPLICATIONS:
Polacrilin Potassium is an effective tablet disintegrant, while
providing the necessary hardness and chemical
stability. It swells up enormously when in contact with
water or gastro-intestinal fluids causing rapid
disintegration without the formation of lumps.. About 0.5 - 5 % Polacrilin Potassium can be added in dry form
to the formulation.
ADVANTAGES:
1) Remarkable-swelling tendency on wetting, causing
rapid disintegration.
2) No lump formation on disintegration.
3) Compatible with commonly used therapeutic agents
and excipients.
4) Works equally efficiently in hydrophilic and
hydrophobic formulations.
5) Gives good mechanical strength to the tablet.
6) Facilitating easy packing and transportation.
7) Does not dissolve or have an adhesive tendency as in
case of gums.
8) Does not stick to punches and dyes.
Characteristics:
Characteristics:
Appearance
|
White to pale cream powder
|
Matrix
|
Copolymer of methacrylic acid and divinyl benzene
|
Functional Group
|
Carboxylic acid
|
Ionic form as supplied
|
Potassium
|
Solubility
|
Insoluble in water and in common solvents
|
Specifications:
Particle size distribution Retained on 100 BSS mesh (150 microns)
|
1.0%, maximum
|
Passing through 200 BSS mesh (75 microns)
|
70%, minimum
|
Moisture content
|
10 %, maximum
|
Sodium content
|
0.2%, maximum
|
Potassium content
|
20.6 - 25.1%
|
pH of 10% slurry
|
7.0 - 9.0
|
Iron content as Fe
|
100 ppm, maximum
|
Heavy metals content as Pb
|
20 ppm, maximum
|
Arsenic content as As
|
3 ppm, maximum
|
READY TO USE GRADES polacrilin potassium USP/NF:
Ready to use grades are drug specific taste masking system enables formulator a single step process. It contains taste masking polymer, sweetener, suspending agent, preservatives, color, flavor and other desire excipients. It is available in various flavors like Banana, Pineapple, Cherry, Strawberry, Peppermint flavor etc. and also as per customer's requirement.
DRUG TO BE MASKED
|
Ciprofloxacin HCI
|
Azithromycin dihydrate
|
Azithromycin dihydrate
|
Ibuprofen
|
DOSE
|
250mg / 5ml
|
100mg / 5ml
|
250mg / 5ml
|
100mg / 5ml
|